Chemoenzymatic synthesis of iminocyclitol derivatives: a useful library strategy for the development of selective fucosyltransfer enzymes inhibitors

R Wischnat; R Martin; S Takayama; C H Wong

doi:10.1016/s0960-894x(98)00617-9

Chemoenzymatic synthesis of iminocyclitol derivatives: a useful library strategy for the development of selective fucosyltransfer enzymes inhibitors

Bioorg Med Chem Lett. 1998 Dec 1;8(23):3353-8. doi: 10.1016/s0960-894x(98)00617-9.

Authors

R Wischnat¹, R Martin, S Takayama, C H Wong

Affiliation

¹ Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA.

PMID: 9873733
DOI: 10.1016/s0960-894x(98)00617-9

Abstract

A chemoenzymatic strategy has been developed for the synthesis of libraries of iminocyclitol derivatives for the discovery of new and selective fucosidase inhibitors.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Enzyme Inhibitors / chemical synthesis*
alpha-L-Fucosidase / antagonists & inhibitors*

Substances

Enzyme Inhibitors
alpha-L-Fucosidase